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Herein we present the exploration of the utility of DNA demethylase enzymes for targeted protein degradation. Novel benzylguanine substrates are characterized for their ability to control protein degradation in cells.… Click to show full abstract
Herein we present the exploration of the utility of DNA demethylase enzymes for targeted protein degradation. Novel benzylguanine substrates are characterized for their ability to control protein degradation in cells. Our data demonstrate the utility of this approach to degrade fusion proteins in different localizations within living cells.
Keywords:
dna repair;
repurposing dna;
targeted protein;
protein degradation;
degradation
Journal Title: ChemBioChem
Year Published: 2022
Link to full text (if available)
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Journal Title: ChemBioChem
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!