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C‐Nitrosothioformamide: A Donor Template for Dual Release of HNO and H2S

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C‐Nitrosothioformamide was demonstrated to be a donor template for dual release of HNO and COS triggered by a retro‐Diels‐Alder reaction. COS is an H2S precursor in the presence of carbonic… Click to show full abstract

C‐Nitrosothioformamide was demonstrated to be a donor template for dual release of HNO and COS triggered by a retro‐Diels‐Alder reaction. COS is an H2S precursor in the presence of carbonic anhydrase. This process produces HNO and H2S in a slow but steady manner. As such, the direct reaction between HNO and H2S under this situation appears to be minor. This may provide a useful tool for studying the synergistic effects of HNO and H2S.

Keywords: template dual; dual release; hno h2s; h2s; donor template

Journal Title: ChemBioChem
Year Published: 2022

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