LAUSR

Peptide mimics, possessing excellent biocompatibility and protease stability, have attracted broad attention and research in the biomedical field. β‐Peptides and β‐peptoids, as two types of vital peptide mimics, have demonstrated great potential in the field of foldamers, antimicrobials and protein binding, etc. Currently, the main synthetic strategies for β‐peptides and β‐peptoids include solid‐phase synthesis and polymerization. Among them, polymerization in one‐pot can minimize the repeated separation and purification used in solid‐phase synthesis, and has the advantages of high efficiency and low cost, and can synthesize β‐peptides and β‐peptoids with high molecular weight. This review summarizes the polymerization methods for β‐peptides and β‐peptoids. Moreover, future developments of the polymerization method for the synthesis of β‐peptides and β‐peptoids will be discussed.