LAUSR

• Critical limb ischemia (CLI) patients with end-stage renal disease (ESRD) undergoing endovascular or open revascularization have 50%–70% lower odds of survival, freedom from amputation, and secondary patency than those without ESRD. • Increased arterial medial calcification, inflammation, comorbidities, and impaired wound healing are the likely causes of worse outcomes in ESRD CLI patients after revascularization compared to other CLI patients without ESRD. • Better risk prediction to inform revascularization decisions and enhanced local wound care are potential avenues for improving outcomes awaiting development of more effective systemic therapies and revascularization approaches for ESRD CLI patients.