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By combining nanocatalysis with base catalysis, a novel one‐pot multistep process was found for the synthesis of substituted heterocycles of biological relevance from simple substrates. The process is based on… Click to show full abstract
By combining nanocatalysis with base catalysis, a novel one‐pot multistep process was found for the synthesis of substituted heterocycles of biological relevance from simple substrates. The process is based on the initial Au/O2 oxidation of allylic alcohols, which is followed by base‐catalyzed tandem hetero‐Michael/aldolization/crotonization with ortho‐hydroxy‐ or ortho‐aminobenzaldehydes. The flexibility of the reaction even allowed the benzaldehyde partner to be prepared in situ in an example of a one‐pot/five‐step process.
Journal Title: ChemCatChem
Year Published: 2017
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