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Copper‐ion‐exchanged nickel pyrazolate frameworks behave as selective heterogeneous catalysts for the one‐pot, two‐step (Henry reaction/Michael type addition) synthesis of neuroactive pharmaceutical intermediates starting from nitromethane and benzaldehyde. Tuning the basicity… Click to show full abstract
Copper‐ion‐exchanged nickel pyrazolate frameworks behave as selective heterogeneous catalysts for the one‐pot, two‐step (Henry reaction/Michael type addition) synthesis of neuroactive pharmaceutical intermediates starting from nitromethane and benzaldehyde. Tuning the basicity of multifunctional metal–organic framework catalysts through ion exchange with copper(II) cations allows the tandem C−C bond‐forming process to be selectively directed towards the desired pharmaceutical intermediate.
Journal Title: ChemCatChem
Year Published: 2017
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