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Transition metal catalyzed cross‐couplings are essential methods in organic synthesis. Due to their comparable low toxicity and price, cobalt‐salts offer a useful alternative to other common metal‐catalysts (e. g. palladium‐complexes). In… Click to show full abstract
Transition metal catalyzed cross‐couplings are essential methods in organic synthesis. Due to their comparable low toxicity and price, cobalt‐salts offer a useful alternative to other common metal‐catalysts (e. g. palladium‐complexes). In this review, we report that cobalt‐catalysts are especially well suited for cross‐coupling reactions with organozinc pivalates, a class of organozinc reagents with enhanced stability towards air and moisture. Furthermore, we discuss applications of cobalt‐catalysis in Negishi cross‐coupling reactions (sp2‐sp2, sp‐sp2, sp‐sp3) as well as electrophilic aminations using organozinc reagents.
Journal Title: ChemCatChem
Year Published: 2019
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