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Highly enantioselective arylation of aryl aldehydes catalyzed by (S)-H8 -BINOL-Ti(Oi-Pr)2 complex in the presence of N-methylmorpholine (NMM) as an effective and inexpensive additive is described for the first time. We… Click to show full abstract
Highly enantioselective arylation of aryl aldehydes catalyzed by (S)-H8 -BINOL-Ti(Oi-Pr)2 complex in the presence of N-methylmorpholine (NMM) as an effective and inexpensive additive is described for the first time. We found high enantioselectivity and yield but successfully reduced the equivalents of nucleophiles triarylaluminums by 50% compared with our previous report. The practicability of the process was thereby greatly increased.
Keywords:
equivalents nucleophiles;
enantioselective arylation;
arylation aryl;
aryl aldehydes;
highly enantioselective;
inexpensive additive
Journal Title: Chirality
Year Published: 2017
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Journal Title: Chirality
Year Published: 2017
Link to full text (if available)
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recommendations!