Photo by narekatsy from unsplash
A novel enantioselective synthesis of (R)-cinacalcet with 99% enantiomeric excesses (ee) has been achieved. The main strategies of the approach include a gram-scale cobalt-catalysed asymmetric cross-coupling of racemic ester with… Click to show full abstract
A novel enantioselective synthesis of (R)-cinacalcet with 99% enantiomeric excesses (ee) has been achieved. The main strategies of the approach include a gram-scale cobalt-catalysed asymmetric cross-coupling of racemic ester with arylzinc reagent, Hoffman-type rearrangement of acidamide, the amidation of chiral amine, and improving the ee of chiral amide from 87% to 99% via recrystallization.
Keywords:
catalysed asymmetric;
cobalt catalysed;
synthesis cinacalcet;
cross coupling;
enantioselective synthesis
Journal Title: Chirality
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Chirality
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!