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An organocatalytic enantioselective Friedel-Crafts alkylation of α-naphthols with isatin derivatives was catalyzed by Takemoto-type urea catalyst to give optical active 3-(naphthalen-2-yl)-3-hydroxy-2-oxindoles in 75%-92% yields with up to 95% enantiomeric excess… Click to show full abstract
An organocatalytic enantioselective Friedel-Crafts alkylation of α-naphthols with isatin derivatives was catalyzed by Takemoto-type urea catalyst to give optical active 3-(naphthalen-2-yl)-3-hydroxy-2-oxindoles in 75%-92% yields with up to 95% enantiomeric excess (ee) value. The catalyst type and the substrate scope were broadened in this methodology.
Keywords:
crafts alkylation;
alkylation naphthols;
enantioselective friedel;
friedel crafts
Journal Title: Chirality
Year Published: 2022
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Journal Title: Chirality
Year Published: 2022
Link to full text (if available)
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recommendations!