Photo from wikipedia
An intriguing example of a crystallization-induced stereochemical switch in the configuration of aza-Michael reaction products is described. Depending on both the stereochemical purity and stoichiometric ratio of the chiral amine… Click to show full abstract
An intriguing example of a crystallization-induced stereochemical switch in the configuration of aza-Michael reaction products is described. Depending on both the stereochemical purity and stoichiometric ratio of the chiral amine used, the reaction delivers crystalline diastereomers of a different stereochemistry. The optically pure diastereomer smoothly converts to its racemic epimer salt upon the addition of a complementary chiral amine.
Keywords:
switch driven;
stereochemical switch;
crystallization;
configuration;
driven crystallization
Journal Title: Chirality
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Chirality
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!