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The synthesis and anti‐HIV evaluation of hitherto unknown 3′‐fluoro‐5′‐norcarbocyclic nucleoside phosphonates bearing adenine with modifications at the 4′ position (ethynyl, vinyl, ethyl, hydroxymethyl) is described. One of the synthesized compounds… Click to show full abstract
The synthesis and anti‐HIV evaluation of hitherto unknown 3′‐fluoro‐5′‐norcarbocyclic nucleoside phosphonates bearing adenine with modifications at the 4′ position (ethynyl, vinyl, ethyl, hydroxymethyl) is described. One of the synthesized compounds was found to be an inhibitor of HIV‐1 replication, but with moderate efficiency relative to (R)‐9‐(2‐phosphonylmethoxypropyl)adenine ((R)‐PMPA, tenofovir), with no concomitant cytotoxicity.
Keywords:
norcarbocyclic nucleoside;
nucleoside phosphonates;
antiviral evaluation;
evaluation fluoro;
synthesis antiviral
Journal Title: ChemMedChem
Year Published: 2019
Link to full text (if available)
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Journal Title: ChemMedChem
Year Published: 2019
Link to full text (if available)
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recommendations!