LAUSR

A series of N- aryl and N- alkyl substituted imidazoles were synthesized and complexed with Ag + to obtain silver-NHC complexes of the form [Ag(NHC)2 ]X. These silver-NHC complexes were tested in-vitro versus the human cell lines HL-60 and MOLM-13 that both model acute myeloid leukemia (AML). A substantial difference in cytotoxicity was revealed varying in the range 13 - 4 μ M (for HL-60) and 22 - 9 μ M (for MOLM-13), respectively. Furthermore, this study revealed that when an alkyl group was installed on the imidazole scaffold, its position influenced substantially the cytotoxicity of the corresponding silver NHC complex.