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Broad‐Spectrum Flavivirus Inhibitors: a Medicinal Chemistry Point of View

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Infections by flaviviruses, such as Dengue, West Nile, Yellow Fever and Zika viruses, represent a growing risk for global health. There are vaccines only for few flaviviruses while no effective… Click to show full abstract

Infections by flaviviruses, such as Dengue, West Nile, Yellow Fever and Zika viruses, represent a growing risk for global health. There are vaccines only for few flaviviruses while no effective treatments are available. Flaviviruses share epidemiological, structural, and ecologic features and often different viruses can co‐infect the same host. Therefore, the identification of broad‐spectrum inhibitors is highly desirable either for known flaviviruses or for viruses that likely will emerge in the future.

Keywords: flavivirus inhibitors; chemistry; inhibitors medicinal; broad spectrum; spectrum flavivirus

Journal Title: ChemMedChem
Year Published: 2020

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