3‐Alkylpyridine alkaloids (3‐APAs) isolated from the arctic sponge Haliclona viscosa are a promising group of bioactive marine alkaloids. However, due to limited bioavailability, investigations of their bioactivity have been hampered.… Click to show full abstract
3‐Alkylpyridine alkaloids (3‐APAs) isolated from the arctic sponge Haliclona viscosa are a promising group of bioactive marine alkaloids. However, due to limited bioavailability, investigations of their bioactivity have been hampered. Additionally, synthesis of a common intermediate requires the use of protecting groups and harsh conditions. In this work, we developed a simple and concise two‐step route to nine different natural and synthetic haliclocyclins. These compounds displayed modest antibiotic activity against several Gram‐positive bacterial strains.
               
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