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This study explores a combined electrochemical and spectroscopic approach to investigate the degradation of bilirubin, a molecular marker of jaundice in humans using a biocompatible nanohybrid (citrate-functionalized Mn 3 O… Click to show full abstract
This study explores a combined electrochemical and spectroscopic approach to investigate the degradation of bilirubin, a molecular marker of jaundice in humans using a biocompatible nanohybrid (citrate-functionalized Mn 3 O 4 ; C-Mn 3 O 4 NH). The approach is aimed at the development of a facile theranostic tool for treatment, detection and prognosis of jaundice. Linear sweep voltammetry (LSV) studies on bilirubin, C-Mn 3 O 4 NH, a model carrier protein and its complex with bilirubin reveal the efficacy of the nanohybrid for both degradation and detection of bilirubin. Furthermore, spectroscopic studies depict that distal electron transfer to be the probable mechanism behind the observed bilirubin degradation in physiological milieu.
Journal Title: ChemMedChem
Year Published: 2022
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