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Phase I cancer trials increasingly incorporate dose‐expansion cohorts (DECs), reflecting a growing demand to acquire more information about investigational drugs. Protocols commonly fail to provide a sample‐size justification or analysis… Click to show full abstract
Phase I cancer trials increasingly incorporate dose‐expansion cohorts (DECs), reflecting a growing demand to acquire more information about investigational drugs. Protocols commonly fail to provide a sample‐size justification or analysis plan for the DEC. In this study, we develop a statistical framework for the design of DECs.
Keywords:
cancer;
phase cancer;
expansion cohorts;
cancer trials
Journal Title: Cancer
Year Published: 2018
Link to full text (if available)
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Journal Title: Cancer
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!