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NPC‐0501 trial on the value of changing chemoradiotherapy sequence, replacing 5‐fluorouracil with capecitabine, and altering fractionation for patients with advanced nasopharyngeal carcinoma

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A current recommendation for the treatment of patients with locoregionally advanced nasopharyngeal carcinoma (NPC) is conventional fractionated radiotherapy (RT) with concurrent cisplatin followed by adjuvant cisplatin and 5‐fluorouracil (PF). This… Click to show full abstract

A current recommendation for the treatment of patients with locoregionally advanced nasopharyngeal carcinoma (NPC) is conventional fractionated radiotherapy (RT) with concurrent cisplatin followed by adjuvant cisplatin and 5‐fluorouracil (PF). This randomized NPC‐0501 trial evaluated the therapeutic effect of changing to an induction‐concurrent sequence or accelerated‐fractionation sequence, and/or replacing 5‐fluorouracil with capecitabine (X).

Keywords: npc 0501; 0501 trial; sequence replacing; advanced nasopharyngeal; nasopharyngeal carcinoma; sequence

Journal Title: Cancer
Year Published: 2020

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