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Prognostic attributes of immune signatures in soft tissue sarcomas show differential dependencies on tumor mutational burden

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Cellular and intrinsic markers of sarcoma immunogenicity are poorly understood. To gain insight into whether tumor–immune interactions correlate with clinical aggressiveness, the authors examined the prognostic significance of immune gene… Click to show full abstract

Cellular and intrinsic markers of sarcoma immunogenicity are poorly understood. To gain insight into whether tumor–immune interactions correlate with clinical aggressiveness, the authors examined the prognostic significance of immune gene signatures in combination with tumor mutational burden (TMB) and cancer–testis antigen (CTA) expression.

Keywords: attributes immune; immune signatures; tumor mutational; prognostic attributes; mutational burden

Journal Title: Cancer
Year Published: 2022

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