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Molecular profiling of patients with cytogenetically normal acute myeloid leukemia and hyperleukocytosis

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Acute myeloid leukemia (AML) with initial hyperleukocytosis is associated with high early mortality and a poor prognosis. The aims of this study were to delineate the underlying molecular landscape in… Click to show full abstract

Acute myeloid leukemia (AML) with initial hyperleukocytosis is associated with high early mortality and a poor prognosis. The aims of this study were to delineate the underlying molecular landscape in the largest cytogenetic risk group, cytogenetically normal acute myeloid leukemia (CN‐AML), and to assess the prognostic relevance of recurrent mutations in the context of hyperleukocytosis and clinical risk factors.

Keywords: cytogenetically normal; acute myeloid; myeloid leukemia; hyperleukocytosis

Journal Title: Cancer
Year Published: 2022

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