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PD‐L1 and thyroid cytology: A possible diagnostic and prognostic marker

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Programmed death‐ligand 1 (PD‐L1) expression is emerging as an important predictive biomarker in anti–PD‐L1 cancer immunotherapy. Its role has been clearly defined in various human cancers and is linked to… Click to show full abstract

Programmed death‐ligand 1 (PD‐L1) expression is emerging as an important predictive biomarker in anti–PD‐L1 cancer immunotherapy. Its role has been clearly defined in various human cancers and is linked to a poor prognosis and resistance to anticancer therapies. The role of PD‐L1 in thyroid cancers has not been well defined in fine‐needle aspiration cytology (FNAC). The authors examined the performance of PD‐L1 immunostaining in liquid‐based cytology (LBC) to determine whether it could be a biomarker of malignancy or aggressive disease.

Keywords: diagnostic prognostic; prognostic marker; possible diagnostic; cytology possible; thyroid cytology; cytology

Journal Title: Cancer Cytopathology
Year Published: 2019

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