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Digital image analysis of high‐grade urothelial carcinoma in urine cytology confirms chromasia heterogeneity and reveals a subset with hypochromatic nuclei and another with extremely dark or “India ink” nuclei

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The Paris System for Reporting Urinary Cytology (TPS) uses hyperchromasia as major diagnostic criterion for high‐grade urothelial carcinoma (HGUC). The purpose of the study was to evaluate cases that were… Click to show full abstract

The Paris System for Reporting Urinary Cytology (TPS) uses hyperchromasia as major diagnostic criterion for high‐grade urothelial carcinoma (HGUC). The purpose of the study was to evaluate cases that were diagnosed as HGUC by TPS and determine whether there are different chromatin distribution patterns (ie, subsets).

Keywords: grade urothelial; high grade; urothelial carcinoma; cytology

Journal Title: Cancer Cytopathology
Year Published: 2022

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