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MicroRNA profiling predicts positive nodal status in papillary thyroid carcinoma in the preoperative setting

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The molecular characterization of thyroid nodules in cytological samples has so far been focused on discriminating between benign and malignant forms in a purely diagnostic setting. The evidence on the… Click to show full abstract

The molecular characterization of thyroid nodules in cytological samples has so far been focused on discriminating between benign and malignant forms in a purely diagnostic setting. The evidence on the impact of molecular biomarkers to determine the risk of aggressiveness in cytologically “neoplastic” lesions is limited to genomic alterations (such as BRAF and TERT mutations). The aim of our study was to assess the preoperative role of microRNAs (miRNAs) in predicting the nodal status of patients with papillary thyroid cancer.

Keywords: papillary thyroid; nodal status; microrna profiling; profiling predicts

Journal Title: Cancer Cytopathology
Year Published: 2022

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