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Neutrophil‐calibrated atypical squamous cells in ThinPrep urine cytology for detecting squamous differentiation in urothelial carcinoma

Urothelial carcinoma with squamous differentiation (UCSD) carries adverse outcomes, yet cytological recognition is challenging because keratinized atypical squamous cells (ASCs) often show deceptively low nuclear‐to‐cytoplasmic ratios. A size‐based ASC classification… Click to show full abstract

Urothelial carcinoma with squamous differentiation (UCSD) carries adverse outcomes, yet cytological recognition is challenging because keratinized atypical squamous cells (ASCs) often show deceptively low nuclear‐to‐cytoplasmic ratios. A size‐based ASC classification anchored to neutrophils was evaluated as a biological internal reference.

Keywords: urothelial carcinoma; squamous cells; atypical squamous; squamous differentiation; cytology

Journal Title: Cancer Cytopathology
Year Published: 2025

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