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The synthesis and catalytic applications of the highly water‐soluble ligand 7‐phospha‐1,3,5‐triaza‐admantane butane sultonate (PTABS) has been described. The synthesized PTABS ligand along with palladium acetate exhibits excellent reactivity towards the… Click to show full abstract
The synthesis and catalytic applications of the highly water‐soluble ligand 7‐phospha‐1,3,5‐triaza‐admantane butane sultonate (PTABS) has been described. The synthesized PTABS ligand along with palladium acetate exhibits excellent reactivity towards the amination reaction of 6‐chloro‐9‐(β‐D‐ribofuranosyl)‐9H‐purine at ambient temperature. This protocol offers an advantage over the previously published procedures for the amination of 6‐chloropurine nucleoside furnishing 6‐N‐substituted adenosine analogues. The validation of the present strategy has been demonstrated via synthesis of a uracil‐based, anti‐diabetic drug alogliptin. © 2018 by John Wiley & Sons, Inc.
Journal Title: Current Protocols in Nucleic Acid Chemistry
Year Published: 2018
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