Photo from wikipedia
For drugs that inhibit organic cation transporters and/or multidrug and toxin extrusion proteins, a metformin clinical drug– drug interaction (DDI) study is recommended to assess the impact on metformin’s systemic… Click to show full abstract
For drugs that inhibit organic cation transporters and/or multidrug and toxin extrusion proteins, a metformin clinical drug– drug interaction (DDI) study is recommended to assess the impact on metformin’s systemic exposure. An oral glucose tolerance test (OGTT) has been proposed as an additional end point to evaluate potential changes in metformin’s efficacy when OCT1 inhibition is suspected. Here, we discuss the limitations of the OGTT in healthy volunteers DDI studies.
Keywords:
tolerance test;
glucose tolerance;
drug drug;
oral glucose;
drug interaction;
drug
Journal Title: Clinical Pharmacology and Therapeutics
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Clinical Pharmacology and Therapeutics
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!