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Bone morphogenetic protein‐2 incorporated calcium phosphate graft promotes peri‐implant bone defect healing in dogs: A pilot study

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The evaluation of three different drug delivery modes of bone morphogenetic protein‐2 (BMP‐2) in healing peri‐implant bone defects in beagle dogs. BMP‐2 was incorporated in or onto calcium phosphate (CaP)… Click to show full abstract

The evaluation of three different drug delivery modes of bone morphogenetic protein‐2 (BMP‐2) in healing peri‐implant bone defects in beagle dogs. BMP‐2 was incorporated in or onto calcium phosphate (CaP) granules in various ways: (i) directly on the outer layer of granules CaP: as an adsorbed depot; (ii) during the entire precipitation process of CaP: an internally incorporated depot; or (iii) during the biomimetic coating precipitation of BMP‐2 on the surface of CaP granules: as a coating incorporated depot.

Keywords: bone; calcium phosphate; peri implant; bone morphogenetic; implant bone; morphogenetic protein

Journal Title: Clinical and Experimental Dental Research
Year Published: 2022

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