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A highly efficient method for the oxidative coupling of 2-substituted 3-oxindoles with aromatic compounds to form 2,2-disubstituted indolin-3-ones with broad scope is described. This work utilized oxygen as the terminal… Click to show full abstract
A highly efficient method for the oxidative coupling of 2-substituted 3-oxindoles with aromatic compounds to form 2,2-disubstituted indolin-3-ones with broad scope is described. This work utilized oxygen as the terminal oxidant and a base-metal catalyst under mild conditions instead of toxic/precious-metal reagents and higher-molecular-weight oxidants. Quaternary structures were produced in modest-to-excellent yields (up to 96 %) without prefunctionalization.
Keywords:
oxindoles indoles;
coupling oxindoles;
indoles arenes;
oxidative coupling
Journal Title: ChemSusChem
Year Published: 2019
Link to full text (if available)
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Journal Title: ChemSusChem
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!