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An iron-catalyzed remote C(sp 3 )-H amination of aliphatic alcohols through 1,5-hydrogen atom transfer is developed. This protocol provides a method to generate δ-C(sp 3 )-N bonds from primary, secondary,… Click to show full abstract
An iron-catalyzed remote C(sp 3 )-H amination of aliphatic alcohols through 1,5-hydrogen atom transfer is developed. This protocol provides a method to generate δ-C(sp 3 )-N bonds from primary, secondary, and tertiary alcohols under mild conditions. A wide substrate scope and a good functional group tolerance are presented. Mechanistic studies show that a LMCT course of an Fe-OR species and a chlorine radical-induced hydrogen abstraction of an alcohol are both possible to generate an alkoxy radical.
Keywords:
light induced;
unactivated sp3;
iron;
induced unactivated;
visible light;
amination
Journal Title: ChemSusChem
Year Published: 2022
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Journal Title: ChemSusChem
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!