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Brain activation during fear extinction predicts exposure success

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Exposure therapy, a gold‐standard treatment for anxiety disorders, is assumed to work via extinction learning, but this has never been tested. Anxious individuals demonstrate extinction learning deficits, likely related to… Click to show full abstract

Exposure therapy, a gold‐standard treatment for anxiety disorders, is assumed to work via extinction learning, but this has never been tested. Anxious individuals demonstrate extinction learning deficits, likely related to less ventromedial prefrontal cortex (vmPFC) and more amygdala activation, but the relationship between these deficits and exposure outcome is unknown. We tested whether anxious individuals who demonstrate better extinction learning report greater anxiety reduction following brief exposure.

Keywords: activation fear; extinction; extinction learning; brain activation; activation; fear extinction

Journal Title: Depression and Anxiety
Year Published: 2017

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