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The association of depression and anxiety with cardiac autonomic activity: The role of confounding effects of antidepressants

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Depression and anxiety may unfavorably impact on cardiac autonomic dysregulation. However, it is unclear whether this relationship results from a causal effect or may be attributable to confounding factors. We… Click to show full abstract

Depression and anxiety may unfavorably impact on cardiac autonomic dysregulation. However, it is unclear whether this relationship results from a causal effect or may be attributable to confounding factors. We tested the relationship between depression and anxiety with heart rate (HR) and heart rate variability (HRV) across a 9‐year follow‐up (FU) period and investigated possible confounding by antidepressant use and genetic pleiotropy.

Keywords: depression; cardiac autonomic; depression anxiety; anxiety cardiac; association depression

Journal Title: Depression and Anxiety
Year Published: 2019

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