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Low omega‐3 polyunsaturated fatty acids predict reduced response to standard antidepressants in patients with major depressive disorder

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Major depressive disorder (MDD) is characterized by a high rate of treatment resistance. Omega (ω)−3 polyunsaturated fatty acids (PUFAs) were shown to correlate with depressive phenotype both in rodents and… Click to show full abstract

Major depressive disorder (MDD) is characterized by a high rate of treatment resistance. Omega (ω)−3 polyunsaturated fatty acids (PUFAs) were shown to correlate with depressive phenotype both in rodents and in humans. However, few studies to date have investigated the role of PUFAs in antidepressant response. The primary aim of this study was to assess the link between baseline PUFA composition and changes in depressive symptoms as well as antidepressant response in a multicenter study of depressed patients.

Keywords: response; fatty acids; omega polyunsaturated; depressive disorder; polyunsaturated fatty; major depressive

Journal Title: Depression and Anxiety
Year Published: 2022

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