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Association of disease course and brain structural alterations in major depressive disorder

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The investigation of disease course‐associated brain structural alterations in Major Depressive Disorder (MDD) have resulted in heterogeneous findings, possibly due to low reliability of single clinical variables used for defining… Click to show full abstract

The investigation of disease course‐associated brain structural alterations in Major Depressive Disorder (MDD) have resulted in heterogeneous findings, possibly due to low reliability of single clinical variables used for defining disease course. The present study employed a principal component analysis (PCA) on multiple clinical variables to investigate effects of cumulative lifetime illness burden on brain structure in a large and heterogeneous sample of MDD patients.

Keywords: structural alterations; disease; brain structural; disease course

Journal Title: Depression and Anxiety
Year Published: 2022

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