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Elucidating behavioral and functional connectivity markers of aberrant threat discrimination in PTSD

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Patients with posttraumatic stress disorder (PTSD) tend to overgeneralize threat to safe stimuli, potentially reflecting aberrant stimuli discrimination. Yet, it is not clear whether threat overgeneralization reflects general discrimination deficits,… Click to show full abstract

Patients with posttraumatic stress disorder (PTSD) tend to overgeneralize threat to safe stimuli, potentially reflecting aberrant stimuli discrimination. Yet, it is not clear whether threat overgeneralization reflects general discrimination deficits, or rather a specific bias related to aversive stimuli. Here we tested this question and characterized the neural correlates of threat discrimination.

Keywords: elucidating behavioral; threat discrimination; behavioral functional; threat; discrimination; ptsd

Journal Title: Depression and Anxiety
Year Published: 2022

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