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Urinary tract washing specimens containing atypical urothelial tissue fragments are significantly associated with urothelial neoplasia

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We previously found that the presence of atypical urothelial tissue fragments (AUTF) was associated with an increased risk of high‐grade urothelial carcinoma (HGUC) but not low‐grade urothelial neoplasia (LGUN) in… Click to show full abstract

We previously found that the presence of atypical urothelial tissue fragments (AUTF) was associated with an increased risk of high‐grade urothelial carcinoma (HGUC) but not low‐grade urothelial neoplasia (LGUN) in voided urine (VU) specimens. However, we subsequently found that patients with LGUN were more likely to have cytologic atypia in urinary washing (UW) specimens, suggesting that cytologic atypia found in UW specimens might be associated with both LGUN and HGUC. In this study, we retrospectively examined UW specimens containing AUTF to determine whether they were associated with HGUC, LGUN, or both HGUC and LGUN.

Keywords: urothelial tissue; urothelial neoplasia; washing specimens; specimens containing; atypical urothelial; tissue fragments

Journal Title: Diagnostic Cytopathology
Year Published: 2017

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