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Metastatic hepatocellular carcinoma masquerading as soft tissue sarcoma: A diagnostic challenge

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Metastasis of visceral malignancies to soft tissue is not very common, the bulk of such malignancies being adenocarcinomas. The commonest primary tumors are lung and breast carcinoma followed by the… Click to show full abstract

Metastasis of visceral malignancies to soft tissue is not very common, the bulk of such malignancies being adenocarcinomas. The commonest primary tumors are lung and breast carcinoma followed by the gastrointestinal tract and female genital tract malignancies. The most common metastatic soft tissue sites are abdominal wall and scapular region followed by thigh and chest wall. In a study by Plaza et al. in 27% of metastatic deposit cases (out of a total of 118 cases), the initial manifestation of internal malignancy was soft tissue deposit which were misinterpreted clinically as soft tissue tumor/sarcoma. We encountered exceedingly rare instances of hepatocellular carcinoma (HCC) with initial presentation as soft tissue mass. The large size of the soft tissue tumor and cytomorphology favored a sarcoma with epithelioid morphology. However, a rare possibility of metastatic carcinoma was considered which was confirmed after Cytokeratin (pan CK) immunohistochemistry (IHC).

Keywords: sarcoma; hepatocellular carcinoma; metastatic hepatocellular; soft tissue; tissue

Journal Title: Diagnostic Cytopathology
Year Published: 2018

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