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Novel cytomorphologic characteristics suggesting human papillomavirus infection in patients diagnosed as negative for intraepithelial lesion or malignancy and a comparison of diagnostic performance of three human papillomavirus tests

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Although the Papanicolaou (Pap) test is the first‐line screening method for cervical cancer, it has low sensitivity for detection of human papillomavirus (HPV)‐infected cervical lesion compared to the HPV test.… Click to show full abstract

Although the Papanicolaou (Pap) test is the first‐line screening method for cervical cancer, it has low sensitivity for detection of human papillomavirus (HPV)‐infected cervical lesion compared to the HPV test. The aims of this study are to determine novel cytomorphologic parameters for HPV infection in patients previously diagnosed as negative for intraepithelial lesion or malignancy (NILM) and to comparatively analyze the detection performance of 3 HPV tests: nested PCR, the DNA Chip test, and the Liquid Beads Microarray (LBMA) assay.

Keywords: infection patients; novel cytomorphologic; diagnosed negative; human papillomavirus; lesion; papillomavirus

Journal Title: Diagnostic Cytopathology
Year Published: 2018

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