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"Atypical Glandular Cells" on Cervical Cytology: Correlation Between Glandular Cell Component Volume and Histological Follow-Up.

Atypical glandular cells (AGC) in cervical cytology, as defined by the Bethesda System, indicate nuclear atypia beyond reactive changes but without definitive features of malignancy. Although clinically significant because it… Click to show full abstract

Atypical glandular cells (AGC) in cervical cytology, as defined by the Bethesda System, indicate nuclear atypia beyond reactive changes but without definitive features of malignancy. Although clinically significant because it prompts follow‐up procedures, no quantitative threshold exists for AGC diagnosis. This study evaluated whether the volume of glandular cell clusters (GCC), regardless of atypia, influences AGC interpretation and may contribute to unnecessary sampling.

Keywords: atypical glandular; glandular cells; cervical cytology; glandular cell; cytology; glandular

Journal Title: Diagnostic cytopathology
Year Published: 2025

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