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Irisin increases the expression of anorexigenic and neurotrophic genes in mouse brain

Irisin, a newly discovered muscle‐derived hormone, acts in different organs and tissues, improving energy homeostasis. In this study, we assessed, for the first time, the effects of intraperitoneal irisin injections… Click to show full abstract

Irisin, a newly discovered muscle‐derived hormone, acts in different organs and tissues, improving energy homeostasis. In this study, we assessed, for the first time, the effects of intraperitoneal irisin injections on circulating levels of leptin and ghrelin, mRNA expression of the major hypothalamic appetite regulators and brain neurotrophic factors, as well as feeding behaviour in healthy mice.

Keywords: increases expression; expression anorexigenic; anorexigenic neurotrophic; irisin; irisin increases; brain

Journal Title: Diabetes/Metabolism Research and Reviews
Year Published: 2019

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