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Comparison of Sodium‐Glucose Cotransporter 2 Inhibitors Versus Glucagon‐Like Peptide‐1 Receptor Agonists and Risks of Osteoarthritis and Arthroplasty in Patients With Type 2 Diabetes Mellitus: A Propensity Score‐Matched Cohorts Retrospective Study

Sodium‐glucose cotransporter 2 inhibitors (SGLT2is) may have the potential to lower the risk of osteoarthritis through an anti‐inflammatory mechanism. This study compared the risks of new‐onset osteoarthritis and joint replacement… Click to show full abstract

Sodium‐glucose cotransporter 2 inhibitors (SGLT2is) may have the potential to lower the risk of osteoarthritis through an anti‐inflammatory mechanism. This study compared the risks of new‐onset osteoarthritis and joint replacement surgery between new users of SGLT2is and new users of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs).

Keywords: cotransporter inhibitors; glucose cotransporter; like peptide; peptide receptor; sodium glucose; glucagon like

Journal Title: Diabetes/Metabolism Research and Reviews
Year Published: 2025

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