LAUSR

The Institute for In Vitro Sciences (IIVS) is sponsoring a series of workshops to develop recommendations for optimal scientific and technical approaches for conducting in vitro assays to assess potential toxicity within and across tobacco and various next generation products (NGPs) including heated tobacco products (HTPs) and electronic nicotine delivery systems (ENDS). This publication was developed by a working group of the workshop members in conjunction with the sixth workshop in that series entitled "Dosimetry for conducting in vitro evaluations". and focuses on aerosol dosimetry for aerosol exposure to combustible cigarettes, HTP and ENDS aerosolized tobacco products and summarizes the key challenges as well as documenting areas for future research. Overall recommendations developed by the working group include the need to 1) fully characterize and understand the smoke or aerosol generating system 2) understand changes in a sample, from smoke or aerosol generation to cell exposure 3) characterize the generated sample 4) define and justify any chosen quantitative dosimetry measurement 5) conduct collaborative studies to facilitate interlaboratory comparisons of dosimetry measurements.