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Apert syndrome is an autosomal, dominant inherited disorder characterized by craniosynostosis and syndactyly caused by gain‐of‐function mutations in the fibroblast growth factor receptor 2 (FGFR2) gene. Wnt/β‐catenin signaling plays critical… Click to show full abstract
Apert syndrome is an autosomal, dominant inherited disorder characterized by craniosynostosis and syndactyly caused by gain‐of‐function mutations in the fibroblast growth factor receptor 2 (FGFR2) gene. Wnt/β‐catenin signaling plays critical roles in regulating the skeletal development. Here, we analyzed the role of this pathway in the developing coronal sutures (CS) of a murine Apert syndrome model (Fgfr2S252W/+).
Keywords:
model;
apert syndrome;
fgfr2s252w;
developing coronal;
coronal sutures;
wnt catenin
Journal Title: Developmental Dynamics
Year Published: 2020
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Journal Title: Developmental Dynamics
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!