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Endochondral growth zone pattern and activity in the zebrafish pharyngeal skeleton

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Endochondral ossification is a major bone forming mechanism in vertebrates, defects in which can result in skeletal dysplasia or craniofacial anomalies in humans. The zebrafish holds great potential to advance… Click to show full abstract

Endochondral ossification is a major bone forming mechanism in vertebrates, defects in which can result in skeletal dysplasia or craniofacial anomalies in humans. The zebrafish holds great potential to advance our understanding of endochondral growth zone development and genetics, yet several important aspects of its biology remain unexplored. Here we provide a comprehensive description of endochondral growth zones in the pharyngeal skeleton, including their developmental progression, cellular activity, and adult fates.

Keywords: growth zone; pharyngeal skeleton; endochondral growth; growth; activity

Journal Title: Developmental Dynamics
Year Published: 2020

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