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Vertebrate eye formation requires coordinated inductive interactions between different embryonic tissue layers, first described in amphibians. A network of transcription factors and signaling molecules controls these steps, with mutations causing… Click to show full abstract
Vertebrate eye formation requires coordinated inductive interactions between different embryonic tissue layers, first described in amphibians. A network of transcription factors and signaling molecules controls these steps, with mutations causing severe ocular, neuronal, and craniofacial defects. In eyeless mutant axolotls, eye morphogenesis arrests at the optic vesicle stage, before lens induction, and development of ventral forebrain structures is disrupted.
Keywords:
eyeless axolotl;
mutated eyeless;
gene mutated;
rax homeobox;
homeobox gene;
axolotl ambystoma
Journal Title: Developmental Dynamics
Year Published: 2020
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Journal Title: Developmental Dynamics
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!