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Defining the critical period of hedgehog pathway inhibitor‐induced cranial base dysplasia in mice

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The hedgehog signaling pathway is critical for developmental patterning of the limb, craniofacial and axial skeleton. Disruption of this pathway in mice leads to a series of structural malformations, but… Click to show full abstract

The hedgehog signaling pathway is critical for developmental patterning of the limb, craniofacial and axial skeleton. Disruption of this pathway in mice leads to a series of structural malformations, but the exact role and critical period of the Hh pathway in the early development of the cranial base have been rarely described.

Keywords: defining critical; mice; critical period; cranial base

Journal Title: Developmental Dynamics
Year Published: 2020

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