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Zebrafish heart regenerates after chemoptogenetic cardiomyocyte depletion

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Zebrafish can regenerate adult cardiac tissue following injuries from ventricular apex amputation, cryoinjury, and cardiomyocyte genetic ablation. Here, we characterize cardiac regeneration from cardiomyocyte chemoptogenetic ablation caused by localized near‐infrared… Click to show full abstract

Zebrafish can regenerate adult cardiac tissue following injuries from ventricular apex amputation, cryoinjury, and cardiomyocyte genetic ablation. Here, we characterize cardiac regeneration from cardiomyocyte chemoptogenetic ablation caused by localized near‐infrared excited photosensitizer‐mediated reactive oxygen species (ROS) generation.

Keywords: heart regenerates; regenerates chemoptogenetic; chemoptogenetic cardiomyocyte; cardiomyocyte depletion; zebrafish heart; cardiomyocyte

Journal Title: Developmental Dynamics
Year Published: 2021

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