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Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial development

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Background: Variation in facial shape may arise from the combinatorial or overlapping actions of paralogous genes. Given its many members, and overlapping expression and functions, the EPH receptor family is… Click to show full abstract

Background: Variation in facial shape may arise from the combinatorial or overlapping actions of paralogous genes. Given its many members, and overlapping expression and functions, the EPH receptor family is a compelling candidate source of craniofacial morphological variation. We performed a detailed morphometric analysis of an allelic series of E14.5 Ephb1‐3 receptor mutants to determine the effect of each paralogous receptor gene on craniofacial morphology.

Keywords: compound paralogous; ephb receptor; effects compound; investigating effects; paralogous ephb; receptor

Journal Title: Developmental Dynamics
Year Published: 2022

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