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Glypican‐6 and Glypican‐4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling

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Glypicans are a family of proteoglycans that play important roles in embryonic morphogenesis. The mammalian genome contains six glypicans (GPC1 to GPC6). GPC6 and GPC4 are the pair of glypicans… Click to show full abstract

Glypicans are a family of proteoglycans that play important roles in embryonic morphogenesis. The mammalian genome contains six glypicans (GPC1 to GPC6). GPC6 and GPC4 are the pair of glypicans that show the highest degree of homology within the family. GPC6‐null embryos display bone abnormalities and severely shortened intestines.

Keywords: growth regulating; glypican glypican; embryonic stomach; stomach growth; stimulate embryonic; glypican stimulate

Journal Title: Developmental Dynamics
Year Published: 2022

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