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Single cell sequencing of the mouse anterior palate reveals mesenchymal heterogeneity

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Cleft palate is one of the most prevalent birth defects. Mice are useful for studying palate development because of their morphological and genetic similarities to humans. In mice, palate development… Click to show full abstract

Cleft palate is one of the most prevalent birth defects. Mice are useful for studying palate development because of their morphological and genetic similarities to humans. In mice, palate development occurs between embryonic days (E)11.5 to 15.5. Single cell transcriptional profiles of palate cell populations have been a valuable resource for the craniofacial research community, but we lack a single cell transcriptional profile for anterior palate at E13.5, at the transition from proliferation to shelf elevation.

Keywords: palate; cell sequencing; single cell; anterior palate; sequencing mouse

Journal Title: Developmental Dynamics
Year Published: 2023

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