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Sacubitril‐Valsartan in a routine community population: attention to volume status critical to achieving target dose

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In the PARADIGM‐heart failure trial, sacubitril‐valsartan demonstrated a reduction in heart failure admissions and reduced all‐cause mortality in patients with heart failure with reduced ejection fraction. Although real world data… Click to show full abstract

In the PARADIGM‐heart failure trial, sacubitril‐valsartan demonstrated a reduction in heart failure admissions and reduced all‐cause mortality in patients with heart failure with reduced ejection fraction. Although real world data have shown similar benefits regarding efficacy and safety, there has been difficulty in achieving the target dose (TD). The factors preventing the achievement of TD remains unclear.

Keywords: achieving target; target dose; sacubitril valsartan; heart failure

Journal Title: ESC Heart Failure
Year Published: 2020

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